(19)

(11)

EP 0 663 839 A1

(12)

(43) Date of publication: 26.07.1995 Bulletin 1995/30 (21) Application number: 93921709.0 (22) Date of filing: 21.09.1993

(51) International Patent Classification (IPC):  A61K 31/ 19( . ) A61K 31/ 415( . ) A61K 31/ 445( . ) A61P 29/ 00( . ) A61K 31/ 34( . ) A61K 31/ 425( . ) A61P 25/ 04( . ) (86) International application number: PCT/US1993/008947 (87) International publication number: WO 1994/007541 (14.04.1994 Gazette 1994/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 29.09.1992 US 19920953440 (71) Applicants: MERCK & CO. INC. Rahway New Jersey 07065-0900 (US) McNEIL-PPC, INC. Milltown New Jersey 08850 (US)	(72) Inventors: SIMS, Robert, T. Holicong, PA 18928 (US) SLIVKA, William Philadelphia, PA 19118 (US) GATES, Thomas, N. Doylestown, PA 18901 (US) MCMAHON, Robert Flemington, NJ 08822 (US) (74) Representative: Cole, William Gwyn, et al  European Patent Department Merck & Co., Inc. Terlings Park Eastwick Road Harlow Essex CM20 2QR Harlow Essex CM20 2QR (GB)