(19)

(11)

EP 0 665 848 A1

(12)

(43) Date of publication: 09.08.1995 Bulletin 1995/32 (21) Application number: 93921262.0 (22) Date of filing: 31.08.1993

(51) International Patent Classification (IPC):  C07H 15/ 04( . ) C07H 17/ 02( . ) C07J 17/ 00( . ) C07H 15/ 203( . ) C07H 17/ 04( . ) (86) International application number: PCT/US1993/008189 (87) International publication number: WO 1994/005678 (17.03.1994 Gazette 1994/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.09.1992 US 19920939008 (71) Applicant: THE UAB RESEARCH FOUNDATION Birmingham Alabama 35294 (US)	(72) Inventors: ESKO, Jeffrey, D. Birmingham, AL 35205 (US) LUGEMWA, Fulgentius, N. Birmingham, AL 35205 (US) FRITZ, Timothy, A. Birmingham, AL 35209 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)