(19)
(11)
EP 0 666 745 A1
(12)
(43)
Date of publication:
16.08.1995
Bulletin 1995/33
(21)
Application number:
92918207.0
(22)
Date of filing:
17.08.1992
(51)
International Patent Classification (IPC):
A61K
31/
505
( . )
A61P
25/
00
( . )
C12Q
1/
68
( . )
A61K
48/
00
( . )
A61K
38/
44
( . )
C12N
9/
06
( . )
C12Q
1/
70
( . )
(86)
International application number:
PCT/US1992/006746
(87)
International publication number:
WO 1993/005783
(
01.04.1993
Gazette 1993/09)
(84)
Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE
(30)
Priority:
20.09.1991
US 19910762302
(71)
Applicant:
THE GENERAL HOSPITAL CORPORATION
Boston, MA 02114 (US)
(72)
Inventors:
BREAKEFIELD, Xandra O.
Newton, MA 02159 (US)
HOTAMISLIGIL, Gokhan S.
Charlestwon, MA 02129-2067 (US)
(74)
Representative:
Wright, Simon Mark, et al
Kilburn & Strode 30 John Street
London WC1N 2DD
London WC1N 2DD (GB)
(54)
DIAGNOSIS AND THERAPY FOR PARKINSON'S DISEASE