(19)
(11) EP 0 666 745 A1

(12)

(43) Date of publication:
16.08.1995 Bulletin 1995/33

(21) Application number: 92918207.0

(22) Date of filing: 17.08.1992
(51) International Patent Classification (IPC): 
A61K 31/ 505( . )
A61P 25/ 00( . )
C12Q 1/ 68( . )
A61K 48/ 00( . )
A61K 38/ 44( . )
C12N 9/ 06( . )
C12Q 1/ 70( . )
(86) International application number:
PCT/US1992/006746
(87) International publication number:
WO 1993/005783 (01.04.1993 Gazette 1993/09)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE

(30) Priority: 20.09.1991 US 19910762302

(71) Applicant: THE GENERAL HOSPITAL CORPORATION
Boston, MA 02114 (US)

(72) Inventors:
  • BREAKEFIELD, Xandra O.
    Newton, MA 02159 (US)
  • HOTAMISLIGIL, Gokhan S.
    Charlestwon, MA 02129-2067 (US)

(74) Representative: Wright, Simon Mark, et al 
Kilburn & Strode 30 John Street
London WC1N 2DD
London WC1N 2DD (GB)

   


(54) DIAGNOSIS AND THERAPY FOR PARKINSON'S DISEASE