(19)
(11)
EP 0 666 867 A1
(12)
(43)
Date of publication:
16.08.1995
Bulletin 1995/33
(21)
Application number:
93921548.0
(22)
Date of filing:
14.09.1993
(51)
International Patent Classification (IPC):
A61K
38/
00
( . )
A61P
29/
00
( . )
C07K
14/
74
( . )
A61K
39/
395
( . )
C07K
7/
08
( . )
C07K
16/
28
( . )
(86)
International application number:
PCT/US1993/008644
(87)
International publication number:
WO 1994/006823
(
31.03.1994
Gazette 1994/08)
(84)
Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
(30)
Priority:
14.09.1992
US 19920943418
(71)
Applicant:
BRIGHAM AND WOMEN'S HOSPITAL
Boston, Massachusetts 02115 (US)
(72)
Inventors:
BRENNER, Michael, B.
Sherborn, MA 01770 (US)
DERSIMONIAN, Harout
Watertown, MA 02172 (US)
(74)
Representative:
Sheard, Andrew Gregory, et al
Kilburn & Strode 30, John Street
London WC1N 2DD
London WC1N 2DD (GB)
(54)
REAGENTS AND METHODS FOR TREATING RHEUMATOID ARTHRITIS