(19)

(11)

EP 0 666 921 A1

(12)

(43) Date of publication: 16.08.1995 Bulletin 1995/33 (21) Application number: 92921633.0 (22) Date of filing: 30.09.1992

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 15/ 82( . ) C07K 14/ 81( . ) (86) International application number: PCT/US1992/008359 (87) International publication number: WO 1993/006713 (15.04.1993 Gazette 1993/10)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 02.10.1991 US 19910770048 (71) Applicant: CORNELL RESEARCH FOUNDATION, INC. Ithaca, NY 14850 (US)	(72) Inventors: WU, Ray Ithaca, NY 14850 (US) McELROY, David 14B Acacia Gardens Lyneham, Canberra ACT 2602 (AU) XU, Deping Ithaca, NY (US) (74) Representative: Allam, Peter Clerk  LLOYD WISE, TREGEAR & CO. Norman House 105-109 Strand London WC2R 0AE London WC2R 0AE (GB)