(19)

(11)

EP 0 666 923 A1

(12)

(43) Date of publication: 16.08.1995 Bulletin 1995/33 (21) Application number: 92920863.0 (22) Date of filing: 04.09.1992

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) A61K 48/ 00( . ) C12N 15/ 87( . ) A61K 47/ 48( . ) C07H 21/ 04( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1992/007339 (87) International publication number: WO 1993/004701 (18.03.1993 Gazette 1993/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 05.09.1991 US 19910755083 04.11.1991 US 19910788119 03.04.1992 US 19920864003 (71) Applicant: THE UNIVERSITY OF CONNECTICUT Storrs, CT 06269 (US)	(72) Inventors: WU, George, Y. Bloomfield, CT 06002 (US) WU, Catherine, H. Bloomfield, CT 06002 (US) (74) Representative: UEXKÜLL & STOLBERG  Patentanwälte Beselerstrasse 4 D-22607 Hamburg D-22607 Hamburg (DE)