(19)
(11) EP 0 667 870 A1

(12)

(43) Date of publication:
23.08.1995 Bulletin 1995/34

(21) Application number: 94900408.0

(22) Date of filing: 26.10.1993
(51) International Patent Classification (IPC): 
C12N 15/ 09( . )
A61P 1/ 00( . )
A61P 9/ 10( . )
A61P 37/ 00( . )
C07H 21/ 02( . )
C07K 14/ 47( . )
C07K 16/ 28( . )
C12P 21/ 02( . )
 A61K 38/ 00( . )
A61P 1/ 16( . )
A61P 29/ 00( . )
A61P 43/ 00( . )
C07H 21/ 04( . )
C07K 14/ 71( . )
C12N 5/ 10( . )
(86) International application number:
PCT/US1993/010307
(87) International publication number:
WO 1994/010187 (11.05.1994 Gazette 1994/11)
(84) Designated Contracting States:
AT BE CH DE DK FR GB IT LI NL SE

(30) Priority: 30.10.1992 US 19920968953
30.10.1992 US 19920968954

(71) Applicants:
  • HSC RESEARCH DEVELOPMENT LIMITED PARTNERSHIP
    Toronto Ontario, M5G 1X8 (CA)
  • MEMORIAL SLOAN-KETTERING CANCER CENTER
    New York, NY 10021 (US)
  • CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    E-28006 Madrid (ES)

(72) Inventors:
  • LETARTE, Michelle
    Toronto, Ontario M4K 2Z7 (CA)
  • MASSAGUE, Joan
    New York, NY 10021 (US)
  • BERNABEU, Carmelo
    E-28006 Madrid (ES)
  • CHEIFETZ, Sela
    Concord, Ontario L4K 2R8 (CA)

(74) Representative: UEXKÜLL & STOLBERG 
Patentanwälte Beselerstrasse 4
D-22607 Hamburg
D-22607 Hamburg (DE)

   


(54) COMPOSITIONS AND METHODS FOR MODIFYING THE REGULATORY ACTIVITY OF TGF-$g(b)