(19)

(11)

EP 0 667 903 A1

(12)

(43) Date of publication: 23.08.1995 Bulletin 1995/34 (21) Application number: 93922677.0 (22) Date of filing: 28.07.1993

(51) International Patent Classification (IPC):  C07K 14/ 505( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1993/007116 (87) International publication number: WO 1994/002611 (03.02.1994 Gazette 1994/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.07.1992 US 19920920810 (71) Applicant: NEW ENGLAND DEACONESS HOSPITAL Boston, MA 02215 (US)	(72) Inventors: SYTKOWSKI, Arthur J. Arlington, MA 02174 (US) GRODBERG, Jennifer Boston, MA 02215 (US) (74) Representative: Holdcroft, James Gerald, Dr., et al  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)