(19)

(11)

EP 0 668 758 A1

(12)

(43) Date of publication: 30.08.1995 Bulletin 1995/35 (21) Application number: 94901276.0 (22) Date of filing: 04.11.1993

(51) International Patent Classification (IPC):  A61K 9/ 28( . ) A61K 9/ 50( . ) A61K 31/ 445( . ) A61K 9/ 20( . ) A61K 9/ 64( . ) A61P 9/ 06( . ) (86) International application number: PCT/US1993/010640 (87) International publication number: WO 1994/009762 (11.05.1994 Gazette 1994/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 05.11.1992 US 19920971882 (71) Applicant: MERCK & CO. INC. Rahway New Jersey 07065-0900 (US)	(72) Inventors: DEMPSKI, Robert, E. Dresher, PA 19025 (US) OLIVERO, Robert, C. Ardsley, PA 19038 (US) SCHOTZ, Edward, C. Blue Bell, PA 19422 (US) (74) Representative: Cole, William Gwyn  European Patent Department Merck & Co., Inc. Terlings Park Eastwick Road Harlow Essex CM20 2QR Harlow Essex CM20 2QR (GB)