(19)

(11)

EP 0 668 925 A1

(12)

(43) Date of publication: 30.08.1995 Bulletin 1995/35 (21) Application number: 92918132.0 (22) Date of filing: 19.08.1992

(51) International Patent Classification (IPC):  C12P 7/ 40( . ) C12R 1/ 72( . ) C12P 41/ 00( . ) (86) International application number: PCT/EP1992/001896 (87) International publication number: WO 1993/004190 (04.03.1993 Gazette 1993/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 22.08.1991 GB 19910181503 (71) Applicant: LABORATORIOS MENARINI S.A. E-08912 Badalona (ES)	(72) Inventors: EVANS, Christopher Thomas Heydon, Hertfordshire SG8 8PU (GB) McCAGUE, Raymond Milton, Cambridgeshire CB4 6EE (GB) TAYLOR, Stephen John Clifford Ely, Cambrigdeshire CB7 4MT (GB) CARGANICO, Germano E-08912 Badalona (ES) (74) Representative: Bianchetti, Giuseppe, et al  Studio Consulenza Brevettuale, Via Rossini, 8 I-20122 Milan I-20122 Milan (IT)