| (19) |
 |
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(11) |
EP 0 669 344 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
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18.12.1996 Bulletin 1996/51 |
| (43) |
Date of publication A2: |
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30.08.1995 Bulletin 1995/35 |
| (22) |
Date of filing: 23.02.1995 |
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| (84) |
Designated Contracting States: |
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AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
| (30) |
Priority: |
25.02.1994 JP 28169/94
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| (71) |
Applicant: DAIICHI PURE CHEMICALS CO. LTD. |
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Chuo-ku
Tokyo (JP) |
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| (72) |
Inventors: |
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- Yago, Hirokazu,
C/o Daiichi Pure Chemicals
Sumida-ku,
Tokyo (JP)
- Hanada, Hisashi,
C/o Daiichi Pure Chemicals
Sumida-ku,
Tokyo (JP)
- Wada, Masato,
c/o Daiichi Pure Chemicals
Sumida-ku,
Tokyo (JP)
- Ushizawa, Koji,
c/o Daiichi Pure Chemicals
Sumida-ku,
Tokyo (JP)
|
| (74) |
Representative: Kraus, Walter, Dr. et al |
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Patentanwälte Kraus, Weisert & Partner
Thomas-Wimmer-Ring 15
D-80539 München
D-80539 München (DE) |
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| (54) |
Monoclonal antibody and immunoassay using the same |
(57) Monoclonal antibodies which exhbit specificity anti-thrombin-antithrombin III complexes
and a method for imunologically measuring the anti-thrombin-antithrombin III complexes.
Because the monoclonal antibodies of the present invention specifically recognize
and exhibit high affinity with thrombin-antithrombin III complexes, they can accurately
determine concentrations of thrombin-antithrombin III complexes in samples without
being affected by cross-reaction products and is thus useful for diagnosis of a blood
clotting tendency.