(19)

(11)

EP 0 669 931 A1

(12)

(43) Date of publication: 06.09.1995 Bulletin 1995/36 (21) Application number: 94902304.0 (22) Date of filing: 18.11.1993

(51) International Patent Classification (IPC):  A61K 31/ 56( . ) A61K 31/ 58( . ) A61K 31/ 59( . ) A61P 35/ 00( . ) C07J 7/ 00( . ) C07J 11/ 00( . ) C07J 31/ 00( . ) C07J 61/ 00( . ) C07J 75/ 00( . ) A61K 31/ 575( . ) A61K 31/ 585( . ) A61K 45/ 06( . ) C07J 3/ 00( . ) C07J 9/ 00( . ) C07J 15/ 00( . ) C07J 41/ 00( . ) C07J 73/ 00( . ) (86) International application number: PCT/US1993/011235 (87) International publication number: WO 1994/011385 (26.05.1994 Gazette 1994/12)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 18.11.1992 GB 19920024148 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventor: WEBB, Robert, Lee West Chester, PA 19380 (US) (74) Representative: Summersell, Richard John  SmithKline Beecham Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)