17-ALPHA AND 17-BETA SUBSTITUTED ACYL-3-CARBOXY-3,5-DIENES AND USE IN INHIBITING 5-ALPHA-REDUCTASE

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EP 0 669 932 A1

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(43)	Date of publication:
	06.09.1995 Bulletin 1995/36

(21)	Application number: 94902307.0

(22)	Date of filing: 18.11.1993

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International Patent Classification (IPC):

A61K 31/ 56^{( . )}
C07J 1/ 00^{( . )}
C07J 5/ 00^{( . )}
C07J 9/ 00^{( . )}
C07J 17/ 00^{( . )}
C07J 33/ 00^{( . )}
C07J 43/ 00^{( . )}

A61P 5/ 00^{( . )}
C07J 3/ 00^{( . )}
C07J 7/ 00^{( . )}
C07J 15/ 00^{( . )}
C07J 31/ 00^{( . )}
C07J 41/ 00^{( . )}
C07J 75/ 00^{( . )}

(86)	International application number:
	PCT/US1993/011241

(87)	International publication number:
	WO 1994/011386 (26.05.1994 Gazette 1994/12)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

18.11.1992 GB 19920024213
14.08.1993 GB 19930016954

(71)	Applicant: SMITHKLINE BEECHAM CORPORATION
	King of Prussia, PA 19406-0939 (US)

(72)	Inventors:
	HOLT, Dennis, Alan Mohnton, PA 19540 (US) LEVY, Mark, Alan Wayne, PA 19087 (US)

(74)	Representative: Summersell, Richard John
	SmithKline Beecham Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)

(54)	17-ALPHA AND 17-BETA SUBSTITUTED ACYL-3-CARBOXY-3,5-DIENES AND USE IN INHIBITING 5-ALPHA-REDUCTASE