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EP 0 669 981 A1

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(43) Date of publication: 06.09.1995 Bulletin 1995/36 (21) Application number: 93924958.0 (22) Date of filing: 19.10.1993

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) C07K 14/ 555( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12N 15/ 20( . ) C12P 21/ 08( . ) C12R 1/ 19( . ) A61K 38/ 21( . ) C07K 16/ 24( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) A61K 38/ 00( . ) C12R 1/ 865( . ) (86) International application number: PCT/US1993/010016 (87) International publication number: WO 1994/010313 (11.05.1994 Gazette 1994/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 30.10.1992 US 19920969890 (60) Divisional application: 03006878.7 / 1360962 (71) Applicants: UNIVERSITY OF FLORIDA Gainesville, Florida 32611-0330 (US) THE WOMEN'S RESEARCH INSTITUTE Wichita, KS 67214 (US)

(72) Inventors: BAZER, Fuller Warren, Center for Animal Biotechn. College Station, TX 77843-2471 (US) JOHNSON, Howard Marcellus, Dept. of Microbiology Gainesville, FL 32611-0330 (US) PONTZER, Carol Hanlon, Department of Microbiology College Park, MD 20742 (US) OTT, Troy Lee, Department of Animal Science College Station TX 77843-2471 (US) VAN HEEKE, Gino CH-4124 Schoenebuch (CH) IMAKAWA, Kazuhiko The Women's Research Institute Wichita, KS 67214 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 D-81675 München D-81675 München (DE)