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(11)

EP 0 670 725 A1

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(43) Date of publication: 13.09.1995 Bulletin 1995/37 (21) Application number: 94902415.0 (22) Date of filing: 24.11.1993

(51) International Patent Classification (IPC):  A61K 9/ 08( . ) A61K 31/ 70( . ) A61K 33/ 00( . ) A61K 33/ 14( . ) A61P 1/ 10( . ) A61K 9/ 00( . ) A61K 31/ 765( . ) A61K 33/ 04( . ) A61K 47/ 36( . ) (86) International application number: PCT/US1993/011479 (87) International publication number: WO 1994/012191 (09.06.1994 Gazette 1994/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.11.1992 US 19920980722 (71) Applicant: BLOCK DRUG COMPANY, INC. Jersey City New Jersey 07302 (US)

(72) Inventors: WILLIAMS, Gregory Charles Lincroft, NJ 07738 (US) VAIDYA, Bhupendra R. Kendall Park, NJ 08824-1611 (US) PARASHOS, Demetra Flushing, NY 11358 (US) BILALI, Essat Palisades Park, NJ 07650 (US) FEARY, Tom Morris Plains, NJ 07950 (US) KAUFMAN, Michele B. Piscataway, NJ 08854 (US) CURRO, Frederick A. Emerson, NJ 07630-1428 (US) (74) Representative: Guerre, Dominique, et al  Cabinet Germain et Maureau 20 Boulevard Eugène Deruelle BP 3011 F-69003 Lyon F-69003 Lyon (FR)