(19)

(11)

EP 0 670 737 A1

(12)

(43) Date of publication: 13.09.1995 Bulletin 1995/37 (21) Application number: 93909173.0 (22) Date of filing: 26.03.1993

(51) International Patent Classification (IPC):  A61K 38/ 55( . ) C07K 14/ 81( . ) A61K 48/ 00( . ) A61K 38/ 57( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1993/002819 (87) International publication number: WO 1993/018794 (30.09.1993 Gazette 1993/24)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI NL (30) Priority: 26.03.1992 US 19920858128 (71) Applicant: GENSIA, INC. San Diego, CA 92121 (US)	(72) Inventors: GRUBER, Harry E. San Diego, CA 92130 (US) ERION, Mark D. Del Mar, CA 92014 (US) MULLANE, Kevin M. Del Mar, CA 92014 (US) FIRESTEIN, Gary S. Del Mar, CA 92014 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)