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EP 0 670 831 A1

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(43) Date of publication: 13.09.1995 Bulletin 1995/37 (21) Application number: 94927085.0 (22) Date of filing: 22.09.1994

(51) International Patent Classification (IPC):  C07D 241/ 44( . ) C07D 401/ 06( . ) C07D 403/ 12( . ) C07D 405/ 14( . ) C07D 413/ 12( . ) C07D 417/ 12( . ) C07D 471/ 04( . ) C07F 7/ 18( . ) C07D 241/ 52( . ) C07D 401/ 12( . ) C07D 405/ 12( . ) C07D 409/ 12( . ) C07D 413/ 14( . ) C07D 417/ 14( . ) C07D 491/ 04( . ) (86) International application number: PCT/JP1994/001559 (87) International publication number: WO 1995/009159 (06.04.1995 Gazette 1995/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.09.1993 JP 19930241140 28.04.1994 JP 19940114639 (71) Applicant: OTSUKA PHARMACEUTICAL CO., LTD. Chiyoda-ku Tokyo 101 (JP)

(72) Inventors: KOMATSU, Makoto, 91-5, Sasagino-Aza Itano-gun, Tokushima 771-02 (JP) SATO, Hideaki, ST-Guran-Naruto 503 Naruto-shi, Tokushima 772 (JP) TAIRA, Shinichi, Ediitaun-Gomaihama B-5 Naruto-shi, Tokushima 772 (JP) MIYAKE, Masahiro, Masters-L-Kitajima 17-102 Itano-gun, Tokushima 771-02 (JP) MAGATA, Kiyohiko, 39-8, Nakakirai-Aza Itano-gun, Tokushima 771-02 (JP) YOSHIDA, Hidehiro Tokushima-shi, Tokushima 770 (JP) UEYAMA, Atsunori Tokushima-shi, Tokushima 770 (JP) NISHI, Takao Itano-gun, Tokushima 771-02 (JP) (74) Representative: von Kreisler, Alek, Dipl.-Chem., et al  Patentanwälte, von Kreisler-Selting-Werner, Bahnhofsvorplatz 1 (Deichmannhaus) D-50667 Köln D-50667 Köln (DE)