RXR HOMODIMER FORMATION AND BRIDGED BICYCLIC AROMATIC COMPOUNDS AND THEIR USE IN MODULATING GENE EXPRESSION - Patent 0671005

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(11)

EP 0 671 005 A1

(12)

(43)	Date of publication:
	13.09.1995 Bulletin 1995/37

(21)	Application number: 94904805.0

(22)	Date of filing: 24.11.1993

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International Patent Classification (IPC):

G01N 33/ 50^{( . )}
A61K 31/ 335^{( . )}
A61K 31/ 36^{( . )}
A61K 31/ 381^{( . )}
A61K 31/ 39^{( . )}
A61P 3/ 02^{( . )}
A61P 17/ 00^{( . )}
A61P 35/ 00^{( . )}
A61P 37/ 00^{( . )}
C07C 63/ 49^{( . )}
C07C 65/ 36^{( . )}
C07C 69/ 76^{( . )}
C07D 311/ 58^{( . )}
C07D 319/ 06^{( . )}
C07D 333/ 22^{( . )}
C07D 339/ 06^{( . )}
C07D 409/ 04^{( . )}
C12N 15/ 09^{( . )}
G01N 33/ 53^{( . )}
G01N 33/ 68^{( . )}

A61K 31/ 19^{( . )}
A61K 31/ 357^{( . )}
A61K 31/ 38^{( . )}
A61K 31/ 385^{( . )}
A61P 3/ 00^{( . )}
A61P 5/ 12^{( . )}
A61P 31/ 12^{( . )}
A61P 35/ 02^{( . )}
A61P 43/ 00^{( . )}
C07C 63/ 66^{( . )}
C07C 69/ 738^{( . )}
C07C 233/ 64^{( . )}
C07D 317/ 30^{( . )}
C07D 327/ 04^{( . )}
C07D 333/ 38^{( . )}
C07D 339/ 08^{( . )}
C07K 14/ 705^{( . )}
G01N 33/ 15^{( . )}
G01N 33/ 566^{( . )}
G01N 33/ 74^{( . )}

(86)	International application number:
	PCT/US1993/011492

(87)	International publication number:
	WO 1994/012880 (09.06.1994 Gazette 1994/13)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

25.11.1992 US 19920982174
25.11.1992 US 19920982305

(71)	Applicants:
	LA JOLLA CANCER RESEARCH FOUNDATION La Jolla, CA 92037 (US) SRI INTERNATIONAL Menlo Park, California 94025-3493 (US)

(72)	Inventors:
	PFAHL, Magnus Solana Beach, CA 92075 (US) ZHANG, Xiao-kun La Jolla, CA 92037 (US) LEHMANN, Jurgen, M. Solana Beach, CA 92075 (US) DAWSON, Marcia, I. Menlo Park, CA 94026 (US) CAMERION, James, F. 881 Linda Vista Moss Beach, CA 94038 (US) HOBBS, Peter, D. Palo Alto, CA 94306 (US) JONG, Ling Sunnyvale, CA 94087 (US)

(74)	Representative: Harding, Charles Thomas, et al
	D. Young & Co. 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)

(54)	RXR HOMODIMER FORMATION AND BRIDGED BICYCLIC AROMATIC COMPOUNDS AND THEIR USE IN MODULATING GENE EXPRESSION