(19)

(11)

EP 0 671 941 A1

(12)

(43) Date of publication: 20.09.1995 Bulletin 1995/38 (21) Application number: 93924412.0 (22) Date of filing: 29.10.1993

(51) International Patent Classification (IPC):  A61K 38/ 17( . ) A61P 29/ 00( . ) C07K 7/ 18( . ) A61P 25/ 04( . ) C07K 7/ 06( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1993/010222 (87) International publication number: WO 1994/011021 (26.05.1994 Gazette 1994/12)

(84) Designated Contracting States: CH DE ES FR GB IT LI SE (30) Priority: 10.11.1992 US 19920974000 (71) Applicant: CORTECH, INC. Denver, CO 80221 (US)

(72) Inventors: CHRONIS, John, C. Lakewood, CO 80227 (US) BLODGETT, James, K. Westminster, CO 80021 (US) GOODFELLOW, Val, Smith Westminster, CO 80030 (US) MARATHE, Manoj, V. Westminster, CO 80021 (US) SPRUCE, Lyle, W. Arvada, CO 80005 (US) WHALLEY, Eric, T. Golden, CO 80403 (US) (74) Representative: Baker, Colin John, et al  Withers & Rogers, 4 Dyer's Buildings, Holborn London EC1N 2JT London EC1N 2JT (GB)