(19)
(11) EP 0 672 160 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
22.09.2010 Bulletin 2010/38

(45) Mention of the grant of the patent:
11.08.2010 Bulletin 2010/32

(21) Application number: 94903405.2

(22) Date of filing: 02.12.1993
(51) International Patent Classification (IPC): 
C12N 15/90(2006.01)
C12N 15/18(2006.01)
 A61K 48/00(2006.01)
C12N 15/27(2006.01)
(86) International application number:
PCT/US1993/011704
(87) International publication number:
WO 1994/012650 (09.06.1994 Gazette 1994/13)

(54)

ACTIVATING EXPRESSION OF AN AMPLIFYING ENDOGENOUS GENE BY HOMOLOGOUS RECOMBINATION

EXPRIMIERUNGSAKTIVATION UND VERVIELFÄLTIGUNG VON ENDOGENEM GEN MIT HOMOLOGER REKOMBINATION

ACTIVATION D'EXPRESSION ET D'AMPLIFICATION D'UN GENE ENDOGENE PAR RECOMBINAISON HOMOLOGUE

(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 03.12.1992 US 985586

(43) Date of publication of application:
20.09.1995 Bulletin 1995/38

(73) Proprietor: Shire Human Genetic Therapies, Inc.
Cambridge, MA 02139 (US)

(72) Inventors:
  • TRECO, Douglas, A.
    Arlington, MA 02174 (US)
  • HEARTLEIN, Michael, W.
    Boxborough, MA 01719 (US)
  • SELDEN, Richard, F.
    Wellesley, MA 02181 (US)

(74) Representative: White, Martin Paul et al
Patents Designs & Brands Ltd. 211 The Colonnades
Liverpool L3 4AB
Liverpool L3 4AB (GB)


(56) References cited: : 
EP-A- 0 117 059
WO-A-91/00361
WO-A-92/10561
US-A- 4 822 736
 WO-A-90/12025
WO-A-91/09955
WO-A-92/20808
   
       
    Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).