(19)

(11)

EP 0 673 433 A1

(12)

(43) Date of publication: 27.09.1995 Bulletin 1995/39 (21) Application number: 94900612.0 (22) Date of filing: 12.11.1993

(51) International Patent Classification (IPC):  C12Q 1/ 02( . ) C12Q 1/ 18( . ) C12N 5/ 071( . ) G01N 33/ 50( . ) (86) International application number: PCT/US1993/010874 (87) International publication number: WO 1994/012662 (09.06.1994 Gazette 1994/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 25.11.1992 US 19920981964 (71) Applicant: MERCK & CO. INC. Rahway New Jersey 07065-0900 (US)	(72) Inventors: HOCHMAN, Jerome Lawrence, KS 66049 (US) LECLUYSE, Edward Lawrence, KS 66049 (US) (74) Representative: Thompson, John Dr.  Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)