(19)

(11)

EP 0 673 438 A1

(12)

(43) Date of publication: 27.09.1995 Bulletin 1995/39 (21) Application number: 93920497.0 (22) Date of filing: 09.09.1993

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) G01N 33/ 53( . ) C12Q 1/ 68( . ) G01N 33/ 574( . ) (86) International application number: PCT/US1993/008446 (87) International publication number: WO 1994/006935 (31.03.1994 Gazette 1994/08)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 11.09.1992 US 19920943512 (71) Applicants: CEPHALON, INC. West Chester, PA 19380 (US) GEORGETOWN UNIVERSITY MEDICAL CENTER Washington, DC 20007 (US)	(72) Inventors: DJAKIEW, Daniel Arlington, VA 22205 (US) LEWIS, Michael E. West Chester, PA 19382 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)