(19)

(11)

EP 0 674 528 A1

(12)

(43) Date of publication: 04.10.1995 Bulletin 1995/40 (21) Application number: 94902482.0 (22) Date of filing: 01.12.1993

(51) International Patent Classification (IPC):  A61K 47/ 28( . ) A61K 31/ 35( . ) A61K 31/ 56( . ) A61K 31/ 58( . ) A61K 38/ 08( . ) A61K 47/ 48( . ) A61K 9/ 00( . ) A61K 31/ 44( . ) A61K 31/ 57( . ) A61K 31/ 70( . ) A61K 47/ 36( . ) (86) International application number: PCT/US1993/011651 (87) International publication number: WO 1994/012217 (09.06.1994 Gazette 1994/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.12.1992 US 19920984445 19.11.1993 US 19930155167 (71) Applicant: INSITE VISION INCORPORATED Alameda, CA 94501 (US)	(72) Inventors: TSAO, Sheng-Wan Hsing-Chu 300 (TW) BOWMAN, Lyle M. Pleasanton, CA 94566 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)