PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS - Patent 0674627

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EP 0 674 627 A1

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(43)	Date of publication:
	04.10.1995 Bulletin 1995/40

(21)	Application number: 94902868.0

(22)	Date of filing: 15.12.1993

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International Patent Classification (IPC):

C07D 253/ 06^{( . )}
A61K 31/ 44^{( . )}
A61K 31/ 443^{( . )}
A61K 31/ 47^{( . )}
A61K 31/ 505^{( . )}
A61K 31/ 519^{( . )}
A61P 43/ 00^{( . )}
C07D 213/ 75^{( . )}
C07D 239/ 42^{( . )}
C07D 239/ 48^{( . )}
C07D 405/ 04^{( . )}
C07D 475/ 04^{( . )}

A61K 31/ 415^{( . )}
A61K 31/ 4418^{( . )}
A61K 31/ 4433^{( . )}
A61K 31/ 495^{( . )}
A61K 31/ 517^{( . )}
A61K 31/ 53^{( . )}
C07D 213/ 73^{( . )}
C07D 231/ 56^{( . )}
C07D 239/ 46^{( . )}
C07D 239/ 70^{( . )}
C07D 409/ 04^{( . )}

(86)	International application number:
	PCT/GB1993/002556

(87)	International publication number:
	WO 1994/014780 (07.07.1994 Gazette 1994/15)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

18.12.1992 GB 19920026377
18.02.1993 GB 19930003221

(71)	Applicant: THE WELLCOME FOUNDATION LIMITED
	London NW1 2BP (GB)

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Inventors:

BIGHAM, Eric, Cleveland
Chapel Hill, NC 27514 (US)
REINHARD, John, Frederick, Jr.
Chapel Hill, NC 27514 (US)
MOORE, Philip Keith
Thornton Heath, Surrey CR7 7HU (GB)
BABBEDGE, Rachel Cecilia
Northwood, Middlesex HA6 3NU (GB)
KNOWLES, Richard Graham, Wellcome Foundation Ltd.
Beckenham, Kent BR3 3BS (GB)
NOBBS, Malcolm Stuart, The Wellcome Foundation Ltd
Beckenham, Kent BR3 3BS (GB)
BULL, Donald, The Wellcome Foundation Ltd.
Beckenham, Kent BR3 3BS (GB)

(54)	PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS