(19)
(11)
EP 0 675 723 A1
(12)
(43)
Date of publication:
11.10.1995
Bulletin 1995/41
(21)
Application number:
94905419.0
(22)
Date of filing:
17.12.1993
(51)
International Patent Classification (IPC):
A61K
31/
565
( . )
A61P
43/
00
( . )
A61K
31/
66
( . )
(86)
International application number:
PCT/US1993/012302
(87)
International publication number:
WO 1994/014455
(
07.07.1994
Gazette 1994/15)
(84)
Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
(30)
Priority:
23.12.1992
US 19920996418
(71)
Applicant:
MERCK & CO. INC.
Rahway New Jersey 07065-0900 (US)
(72)
Inventor:
WHITEFORD, Donna, T.
Brooklyn, NY 11201 (US)
(74)
Representative:
Cole, William Gwyn
European Patent Department Merck & Co., Inc. Terlings Park Eastwick Road
Harlow Essex CM20 2QR
Harlow Essex CM20 2QR (GB)
(54)
BISPHOSPHONATE/ESTROGEN THERAPY FOR TREATING AND PREVENTING BONE LOSS