(19)

(11)

EP 0 675 735 A1

(12)

(43) Date of publication: 11.10.1995 Bulletin 1995/41 (21) Application number: 94907806.0 (22) Date of filing: 12.01.1994

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 38/ 17( . ) A61P 1/ 02( . ) A61P 7/ 06( . ) A61P 11/ 00( . ) A61P 15/ 00( . ) A61P 29/ 00( . ) A61P 37/ 00( . ) A61P 39/ 02( . ) C07K 16/ 28( . ) C12P 21/ 08( . ) A61K 38/ 00( . ) A61K 39/ 395( . ) A61P 3/ 08( . ) A61P 9/ 10( . ) A61P 13/ 02( . ) A61P 25/ 00( . ) A61P 35/ 00( . ) A61P 37/ 08( . ) A61P 43/ 00( . ) C12N 15/ 09( . ) G01N 33/ 577( . ) (86) International application number: PCT/US1994/000416 (87) International publication number: WO 1994/015641 (21.07.1994 Gazette 1994/17)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 12.01.1993 US 19930003258 (71) Applicant: THE ROCKEFELLER UNIVERSITY New York, NY 10021 (US)	(72) Inventor: MULLER, William A., Apartment 14D New York, NY 10021 (US) (74) Representative: Mercer, Christopher Paul, et al  Carpmaels & Ransford 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)