(19)

(11)

EP 0 676 959 A1

(12)

(43) Date of publication: 18.10.1995 Bulletin 1995/42 (21) Application number: 94904877.0 (22) Date of filing: 21.12.1993

(51) International Patent Classification (IPC):  A61K 31/ 40( . ) A61K 31/ 404( . ) A61P 9/ 12( . ) A61P 15/ 00( . ) C07D 209/ 30( . ) C07D 405/ 06( . ) A61K 31/ 403( . ) A61P 9/ 00( . ) A61P 13/ 02( . ) A61P 43/ 00( . ) C07D 405/ 04( . ) (86) International application number: PCT/US1993/012435 (87) International publication number: WO 1994/014434 (07.07.1994 Gazette 1994/15)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 22.12.1992 US 19920995466 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventors: ELLIOTT, John Duncan Wayne, PA 19087 (US) LEBER, Jack Dale Warminster, PA 18974 (US) (74) Representative: Florence, Julia Anne, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)