(19)

(11)

EP 0 677 041 A1

(12)

(43) Date of publication: 18.10.1995 Bulletin 1995/42 (21) Application number: 94905503.0 (22) Date of filing: 22.12.1993

(51) International Patent Classification (IPC):  C07D 207/ 08( . ) A61K 31/ 401( . ) A61P 9/ 10( . ) C07D 207/ 16( . ) A61K 31/ 40( . ) A61P 7/ 02( . ) C07D 207/ 12( . ) (86) International application number: PCT/US1993/012531 (87) International publication number: WO 1994/015913 (21.07.1994 Gazette 1994/17)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 30.12.1992 US 19920998356 18.10.1993 US 19930138909 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventor: SAMANEN, James Phoenixville, PA 19460 (US) (74) Representative: Valentine, Jill Barbara, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)