(19)

(11)

EP 0 677 062 A1

(12)

(43) Date of publication: 18.10.1995 Bulletin 1995/42 (21) Application number: 94905569.0 (22) Date of filing: 30.12.1993

(51) International Patent Classification (IPC):  A61K 38/ 23( . ) A61P 3/ 14( . ) C07K 14/ 585( . ) A61P 3/ 00( . ) C07K 14/ 575( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1993/012692 (87) International publication number: WO 1994/015962 (21.07.1994 Gazette 1994/17)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 31.12.1992 US 19920999749 (71) Applicants: ZYMOGENETICS, INC. Seattle, WA 98105 (US) THE UNIVERSITY OF WASHINGTON Seattle, WA 98195 (US)	(72) Inventors: LABROO, Virender Mill Creek, WA 98012 (US) SASAKI, Tomikazu Seattle, WA 98109 (US) (74) Representative: Brown, John David  FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 D-80801 München D-80801 München (DE)