(19)

(11)

EP 0 679 083 A1

(12)

(43) Date of publication: 02.11.1995 Bulletin 1995/44 (21) Application number: 94909422.0 (22) Date of filing: 20.12.1993

(51) International Patent Classification (IPC):  A61K 39/ 44( . ) A61K 31/ 545( . ) A61K 47/ 48( . ) A61P 31/ 04( . ) C07K 7/ 62( . ) C07K 14/ 435( . ) G01N 33/ 532( . ) A61K 38/ 00( . ) A61K 31/ 43( . ) A61K 31/ 70( . ) A61P 31/ 00( . ) C07K 7/ 58( . ) C07K 9/ 00( . ) C07K 16/ 00( . ) G01N 33/ 569( . ) (86) International application number: PCT/US1993/012381 (87) International publication number: WO 1994/014437 (07.07.1994 Gazette 1994/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.12.1992 US 19920995388 08.12.1993 US 19930164067 17.12.1993 US 19930169701 (71) Applicant: OPHIDIAN PHARMACEUTICALS, INC. Madison, WI 53711 (US)	(72) Inventors: CARROLL, Sean B. Cottage Grove, WI 53527 (US) FIRCA, Joseph R. Vernon Hills, IL 60061 (US) PUGH, Charles S.G. Madison, WI 53711 (US) PADHYE, Nisha Vikas Madison, WI 53719 (US) (74) Representative: Glawe, Delfs, Moll & Partner  Patentanwälte Liebherrstrasse 20 D-80538 München D-80538 München (DE)