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(11)

EP 0 679 086 A1

(12)

(43) Date of publication: 02.11.1995 Bulletin 1995/44 (21) Application number: 94904249.0 (22) Date of filing: 13.01.1994

(51) International Patent Classification (IPC):  A61K 45/ 06( . ) A61K 31/ 52( . ) A61K 31/ 70( . ) A61P 35/ 00( . ) A61K 31/ 41( . ) A61K 31/ 522( . ) A61K 31/ 708( . ) (86) International application number: PCT/GB1994/000065 (87) International publication number: WO 1994/015615 (21.07.1994 Gazette 1994/17)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 14.01.1993 US 19930004754 (60) Divisional application: 98119295.8 / 0922458 (71) Applicant: CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED London NW1 4JL (GB)

(72) Inventors: BAER, John Colin London NW1 1HZ (GB) FREEMAN, Azadeh Alison Croydon CR4 3SB (GB) NEWLANDS, Edward Stuart London NW1 4QP (GB) WATSON, Amanda Jean Cheshire SK14 2SW (GB) RAFFERTY, Joseph Anthony Cheshire SK3 9LJ (GB) MARGISON, Geoffrey Paul Poynton Cheshire SK12 1TH (GB) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)