(19)

(11)

EP 0 679 095 A1

(12)

(43) Date of publication: 02.11.1995 Bulletin 1995/44 (21) Application number: 94907044.0 (22) Date of filing: 24.11.1993

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) C07K 14/ 65( . ) (86) International application number: PCT/US1993/011458 (87) International publication number: WO 1994/012219 (09.06.1994 Gazette 1994/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 25.11.1992 US 19920980519 (71) Applicant: SYNERGEN, INC. Boulder Colorado 80301 (US)	(72) Inventors: COX, George N. Louisville, CO 80027 (US) MCDERMOTT, Martin J. Boulder, CO 80302 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 D-80538 München D-80538 München (DE)