(19)

(11)

EP 0 679 185 A1

(12)

(43) Date of publication: 02.11.1995 Bulletin 1995/44 (21) Application number: 94920844.0 (22) Date of filing: 12.01.1994

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61P 35/ 00( . ) C07K 14/ 47( . ) C12N 15/ 12( . ) C12R 1/ 91( . ) A61K 38/ 00( . ) A61P 43/ 00( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1994/000198 (87) International publication number: WO 1994/016069 (21.07.1994 Gazette 1994/17)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 15.01.1993 US 19930004824 (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)	(72) Inventors: NAKAFUKU, Masato Tokyo 187 (JP) KAZIRO, Yoshito Tokyo 177 (JP) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)