(19)
(11)
EP 0 679 192 A1
(12)
(43)
Date of publication:
02.11.1995
Bulletin 1995/44
(21)
Application number:
94900069.0
(22)
Date of filing:
17.11.1993
(51)
International Patent Classification (IPC):
C12N
15/
09
( . )
C12P
21/
00
( . )
C07K
14/
755
( . )
A61K
38/
00
( . )
(86)
International application number:
PCT/DK1993/000375
(87)
International publication number:
WO 1994/011525
(
26.05.1994
Gazette 1994/12)
(84)
Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
(30)
Priority:
17.11.1992
US 19920977356
08.04.1993
US 19930044865
(71)
Applicant:
NOVO NORDISK A/S
DK-2880 Bagsvaerd (DK)
(72)
Inventors:
RASMUSSEN, Mirella Ezban
DK-2100 Copenhagen (DK)
KONGERSLEV, Leif
DK-3460 Birkeroed (DK)
(74)
Representative:
Nilausen, Kim, et al
c/o Novo Nordisk A/S, Corporate Patents, Novo Allé
DK-2880 Bagsvaerd
DK-2880 Bagsvaerd (DK)
(54)
IMPROVED RECOMBINANT PRODUCTION OF PROTEINS HAVING FACTOR VIII:C ACTIVITY