SEQUENTIAL TARGETING OF TUMOR SITES WITH OLIGONUCLEOTIDE CONJUGATES OF ANTIBODY AND COMPLEMENTARY OLIGONUCLEOTIDE CONJUGATES OF CHELATED RADIONUCLIDE - Patent 0680335

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EP 0 680 335 A1

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(43)	Date of publication:
	08.11.1995 Bulletin 1995/45

(21)	Application number: 94903374.0

(22)	Date of filing: 30.11.1993

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International Patent Classification (IPC):

G01N 33/ 566^{( . )}
A61K 47/ 48^{( . )}
C07H 21/ 00^{( . )}
C12N 15/ 09^{( . )}

A61K 39/ 44^{( . )}
A61K 51/ 10^{( . )}
C07H 21/ 04^{( . )}
C12P 21/ 08^{( . )}

(86)	International application number:
	PCT/US1993/011637

(87)	International publication number:
	WO 1994/012216 (09.06.1994 Gazette 1994/13)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

30.11.1992 US 19920985699

(71)	Applicant: THE WELLCOME FOUNDATION LIMITED
	London NW1 2BP (GB)

(72)	Inventors:
	SNOW, Robert, A. West Chester, PA 19380 (US) GROVES, Eric, S. Malvern, PA 19355 (US) SHEARMAN, Clyde W. West Chester, PA 19382 (US) SAHA, Askis, K. Frazer, PA 19355 (US) SEN, Arup Dallas, TX 75209 (US) BLACK, Christopher, D., V. Silver Spring, MD 20906 (US)

(74)	Representative: Baker-Munton, Nicola Jane, et al
	The Wellcome Foundation Limited Langley Court Beckenham Kent BR3 3BS Beckenham Kent BR3 3BS (GB)

(54)	SEQUENTIAL TARGETING OF TUMOR SITES WITH OLIGONUCLEOTIDE CONJUGATES OF ANTIBODY AND COMPLEMENTARY OLIGONUCLEOTIDE CONJUGATES OF CHELATED RADIONUCLIDE