(19)
(11) EP 0 680 472 A1

(12)

(43) Date of publication:
08.11.1995 Bulletin 1995/45

(21) Application number: 94931591.0

(22) Date of filing: 09.11.1994
(51) International Patent Classification (IPC): 
A61K 31/ 415( . )
A61K 31/ 44( . )
A61K 31/ 443( . )
A61P 9/ 10( . )
A61P 15/ 00( . )
C07D 233/ 84( . )
C07D 405/ 12( . )
C07D 487/ 04( . )
A61K 31/ 425( . )
A61K 31/ 4427( . )
A61P 9/ 08( . )
A61P 13/ 02( . )
A61P 43/ 00( . )
C07D 401/ 12( . )
C07D 417/ 12( . )
(86) International application number:
PCT/EP1994/003684
(87) International publication number:
WO 1995/014673 (01.06.1995 Gazette 1995/23)
(84) Designated Contracting States:
DE ES FR GB IT NL SE

(30) Priority: 22.11.1993 IT 1993MI02468

(71) Applicant: PHARMACIA S.p.A.
I-20152 Milano (IT)

(72) Inventors:
  • GOBETTI, Marino
    I-20152 Milan (IT)
  • PALLADINO, Massimiliano
    I-20025 Legnano (IT)
  • VANOTTI, Ermes
    I-20148 Milan (IT)
  • VILLA, Manuela
    I-22040 Lurago d'Erba (IT)
  • BANI, Massimo
    I-20020 Arese (IT)
  • BORMETTI, Rita
    I-20145 Milan (IT)
  • OLGIATI, Vincenzo
    I-20010 Casorezzo (IT)

(74) Representative: Ferrario, Vittorino 
Pharmacia S.p.A. Patent Department Via Bisceglie, 104
I-20152 Milano
I-20152 Milano (IT)

   


(54) 4,5-DIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ACYL COENZYME A: CHOLESTEROL-0-ACYL-TRANSFERASE (ACAT) INHIBITOR