(19)

(11)

EP 0 681 484 A1

(12)

(43) Date of publication: 15.11.1995 Bulletin 1995/46 (21) Application number: 94907897.0 (22) Date of filing: 26.01.1994

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 49/ 00( . ) A61K 51/ 10( . ) C07K 16/ 00( . ) A61K 39/ 44( . ) A61K 51/ 00( . ) A61P 35/ 00( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1994/000965 (87) International publication number: WO 1994/016741 (04.08.1994 Gazette 1994/18)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.01.1993 US 19930010544 (71) Applicant: THE WELLCOME FOUNDATION LIMITED London NW1 2BP (GB)	(72) Inventors: SNOW, Robert Allen West Chester, PA 19380 (US) BLACK, Christopher Douglas Valiant Silver Spring, MD 20906 (US) SHEARMAN, Clyde William West Chester, PA 19382 (US) (74) Representative: Baker-Munton, Nicola Jane  The Wellcome Foundation Limited Langley Court Beckenham Kent BR3 3BS Beckenham Kent BR3 3BS (GB)