(19)

(11)

EP 0 681 582 A1

(12)

(43) Date of publication: 15.11.1995 Bulletin 1995/46 (21) Application number: 94905468.0 (22) Date of filing: 30.12.1993

(51) International Patent Classification (IPC):  A61K 31/ 50( . ) A61P 9/ 12( . ) A61P 15/ 00( . ) A61P 27/ 02( . ) C07D 487/ 04( . ) C07D 487/ 18( . ) A61P 9/ 00( . ) A61P 13/ 02( . ) A61P 19/ 06( . ) A61P 27/ 06( . ) C07D 487/ 08( . ) (86) International application number: PCT/US1993/012447 (87) International publication number: WO 1994/017069 (04.08.1994 Gazette 1994/18)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.01.1993 JP 19930012780 09.04.1993 JP 19930083640 27.09.1993 JP 19930239827 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)

(72) Inventors: KOH, Keiko Tsukuba-shi, Ibaragi-ken 305 (JP) TANIGUCHI, Mikio Tsukuba-shi, Ibaragi-ken 305 (JP) KUSHIDA, Hiroshi Shimodate-shi, Ibaragi-ken 308 (JP) MORITA, Osamu Tsukuba-shi, Ibaragi-ken 305 (JP) YAMADA, Hiroyoshi Tsukuba-shi, Ibaragi-ken 305 (JP) MUNESADA, Kiyotaka Shimotsuma-shi, Ibaragi-ken 304 (JP) KUNIHARA, Mineo Tsukuba-shi, Ibaragi-ken 305 (JP) FUJITA, Yoshiji Abiko-shi, Chiba-ken 270-22 (JP) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)