(19)

(11)

EP 0 682 519 A1

(12)

(43) Date of publication: 22.11.1995 Bulletin 1995/47 (21) Application number: 94909558.0 (22) Date of filing: 03.02.1994

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) C07H 19/ 04( . ) (86) International application number: PCT/US1994/001340 (87) International publication number: WO 1994/017803 (18.08.1994 Gazette 1994/19)

(84) Designated Contracting States: CH DE FR GB IT LI (30) Priority: 03.02.1993 US 19930014190 (71) Applicant: GENSIA, INC. San Diego, CA 92121 (US)

(72) Inventors: FIRESTEIN, Gary Steven Del Mar, CA 92014 (US) UGARKAR, Bheemarao Ganapatrao Escondido, CA 92025 (US) MILLER, Leonard Paul Carlsbad, CA 92009 (US) GRUBER, Harry Edward Rancho Santa Fe, CA 92067 (US) BULLOUGH, David Andrew San Diego, CA 92129 (US) ERION, Mark David Del Mar, CA 92104 (US) CASTELLINO, Angelo John San Diego, CA 92111 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)