(19)

(11)

EP 0 682 525 A1

(12)

(43) Date of publication: 22.11.1995 Bulletin 1995/47 (21) Application number: 94908700.0 (22) Date of filing: 03.02.1994

(51) International Patent Classification (IPC):  A61K 38/ 18( . ) (86) International application number: PCT/US1994/001227 (87) International publication number: WO 1994/017818 (18.08.1994 Gazette 1994/19)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 08.02.1993 US 19930015218 03.09.1993 US 19930116440 (71) Applicant: THE SYNTEX-SYNERGEN NEUROSCIENCE JOINT VENTURE Boulder, Colorado 80301 (US)	(72) Inventors: COLLINS, Frank Agoura Hills, CA 91301 (US) DIETZ, Mark Boulder, CO 80304 (US) (74) Representative: Schumann, Klaus, Dr. rer. nat., et al  Patentanwälte Grünecker, Kinkeldey, Stockmair & Partner Maximilianstrasse 58 D-80538 München D-80538 München (DE)