(19)

(11)

EP 0 682 702 A1

(12)

(43) Date of publication: 22.11.1995 Bulletin 1995/47 (21) Application number: 94905785.0 (22) Date of filing: 04.02.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 9/ 48( . ) C12N 15/ 12( . ) A61K 38/ 00( . ) C12N 5/ 10( . ) C12N 9/ 64( . ) C12N 15/ 57( . ) C12R 1/ 91( . ) (86) International application number: PCT/GB1994/000204 (87) International publication number: WO 1994/018320 (18.08.1994 Gazette 1994/19)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.02.1993 GB 19930002302 (71) Applicants: Mallinckrodt Veterinary, Inc. Mundelein Illinois 60060 (US) THE BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL Cambridge CB2 4AT (GB)	(72) Inventors: MUNN, Edward Fulbourn, Cambridge CB1 5ES (GB) GRAHAM, Margaret Linton, Cambridge CB1 6XQ (GB) SMITH, Trevor Stanley Linton, Cambridge CB1 6UQ (GB) ROLPH, Timothy Peter Wheatley, Oxon OX33 1TR (GB) NEWTON, Susan Elizabeth Strathmore, VIC 3401 (AU) (74) Representative: Dzieglewska, Hanna Eva  Frank B. Dehn & Co. Imperial House 15-19 Kingsway London WC2B 6UZ London WC2B 6UZ (GB)