(19)

(11)

EP 0 683 660 A1

(12)

(43) Date of publication: 29.11.1995 Bulletin 1995/48 (21) Application number: 94909527.0 (22) Date of filing: 10.02.1994

(51) International Patent Classification (IPC):  C07H 21/ 04( . ) A61K 8/ 31( . ) A61K 8/ 34( . ) A61K 8/ 37( . ) A61K 8/ 64( . ) A61K 35/ 64( . ) A61P 43/ 00( . ) A61Q 7/ 00( . ) A61K 8/ 00( . ) A61K 8/ 33( . ) A61K 8/ 36( . ) A61K 8/ 39( . ) A61K 8/ 86( . ) A61K 38/ 00( . ) A61Q 5/ 00( . ) (86) International application number: PCT/US1994/001202 (87) International publication number: WO 1994/017778 (18.08.1994 Gazette 1994/19)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 12.02.1993 US 19930017061 (71) Applicants: SHISEIDO COMPANY LIMITED Chuo-ku Tokyo 104-10 (JP) PRESIDENT AND FELLOWS OF HARVARD COLLEGE Cambridge Massachusetts 02138 (US)

(72) Inventors: RIBEIRO, Jose, M., C. Tucson, AZ 85718 (US) LERNER, Ethan, A. Brookline, MA 02146 (US) REMOLD, Heinz, G. Brookline, MA 02146 (US) TITUS, Richard, G. Needham, MA 02192 (US) TSUJI, Yoshiharu, The Shiseido Research Center Yokohama-shi, Kanagawa (JP) HANSAWA, Chika, The Shiseido Research Center Yokohama-shi, Kanagawa (JP) UZUKA, Makoto, The Shiseido Research Center Yokohama-shi, Kanagawa (JP) (74) Representative: Ahner, Francis, et al  CABINET REGIMBEAU 26, avenue Kléber F-75116 Paris F-75116 Paris (FR)