(19)

(11)

EP 0 684 817 A1

(12)

(43) Date of publication: 06.12.1995 Bulletin 1995/49 (21) Application number: 94906813.0 (22) Date of filing: 17.02.1994

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 31/ 138( . ) A61K 31/ 335( . ) A61K 31/ 445( . ) A61K 31/ 505( . ) A61K 31/ 54( . ) A61K 45/ 00( . ) A61P 35/ 00( . ) C07C 217/ 20( . ) A61K 31/ 135( . ) A61K 31/ 17( . ) A61K 31/ 415( . ) A61K 31/ 495( . ) A61K 31/ 535( . ) A61K 31/ 55( . ) A61K 45/ 06( . ) C07C 217/ 18( . ) C07C 217/ 22( . ) (86) International application number: PCT/CA1994/000087 (87) International publication number: WO 1994/018961 (01.09.1994 Gazette 1994/20)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 17.02.1993 GB 19930003210 (71) Applicant: UNIVERSITY OF MANITOBA Winnipeg, Manitoba R3T 2NZ (CA)	(72) Inventors: BRANDES, Lorne J. Winnipeg, Manitoba R3N 1A3 (CA) REID, Ron Faculty of Pharmaceutical Science Vancouver, British Columbia V6T 1Z3 (CA) (74) Representative: Burford, Anthony Frederick, et al  W.H. Beck, Greener & Co. 7 Stone Buildings Lincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)