(19)
(11) EP 0 684 828 A1

(12)

(43) Date of publication:
06.12.1995 Bulletin 1995/49

(21) Application number: 94910691.0

(22) Date of filing: 15.02.1994
(51) International Patent Classification (IPC): 
C12P 21/ 08( . )
A61K 38/ 00( . )
A61K 38/ 22( . )
A61P 7/ 00( . )
C12N 5/ 0789( . )
 A61K 35/ 28( . )
A61K 38/ 17( . )
A61K 39/ 395( . )
C07K 16/ 22( . )
A61K 35/ 12( . )
(86) International application number:
PCT/US1994/001634
(87) International publication number:
WO 1994/018991 (01.09.1994 Gazette 1994/20)
(84) Designated Contracting States:
DE ES FR GB IT

(30) Priority: 19.02.1993 US 19930019556

(71) Applicants:
  • CELTRIX PHARMACEUTICALS, INC.
    Santa Clara, CA 95054-1815 (US)
  • Oklahoma Medical Research Foundation
    Oklahoma City Oklahoma 73104 (US)

(72) Inventors:
  • WAEGELL, Wendy
    Palo Alto, CA 94043 (US)
  • DASCH, James
    Redwood City, CA 94062 (US)
  • KINCADE, Paul W.
    Oklahoma City, OK 73120 (US)

(74) Representative: Goldin, Douglas Michael, et al 
J.A. KEMP & CO. 14, South Square Gray's Inn
London WC1R 5LX
London WC1R 5LX (GB)

   


(54) EXPANSION OF STEM CELLS IN LONG TERM BONE MARROW CULTURES BY NEUTRALIZATION OF TGF-$g(b)