ROLE OF ATP-UBIQUITIN-DEPENDENT PROTEOLYSIS IN MHC-1 RESTRICTED ANTIGEN PRESENTATION AND INHIBITORS THEREOF - Patent 0684829

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EP 0 684 829 A1

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(43)	Date of publication:
	06.12.1995 Bulletin 1995/49

(21)	Application number: 94908690.0

(22)	Date of filing: 27.01.1994

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International Patent Classification (IPC):

A61K 38/ 00^{( . )}
A61K 38/ 55^{( . )}
A61P 37/ 00^{( . )}
C07K 14/ 81^{( . )}

A61K 38/ 46^{( . )}
A61K 45/ 00^{( . )}
A61P 43/ 00^{( . )}

(86)	International application number:
	PCT/US1994/001183

(87)	International publication number:
	WO 1994/017816 (18.08.1994 Gazette 1994/19)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

10.02.1993 US 19930016066

(71)	Applicants:
	THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE Cambridge, MA 02138 (US) DANA FARBER CANCER INSTITUTE Boston Massachusetts 02115 (US)

(72)	Inventors:
	GOLDBERG, Alfred L. Brookline, MA 02167 (US) ROCK, Kenneth L. Chestnut Hill, MA 02167 (US)

(74)	Representative: White, Martin Paul, et al
	Kilburn & Strode, 30 John Street London WC1N 2DD London WC1N 2DD (GB)

(54)	ROLE OF ATP-UBIQUITIN-DEPENDENT PROTEOLYSIS IN MHC-1 RESTRICTED ANTIGEN PRESENTATION AND INHIBITORS THEREOF