(19)

(11)

EP 0 684 838 A1

(12)

(43) Date of publication: 06.12.1995 Bulletin 1995/49 (21) Application number: 94908327.0 (22) Date of filing: 15.02.1994

(51) International Patent Classification (IPC):  C12N 15/ 00( . ) A61K 39/ 145( . ) A61K 9/ 127( . ) A61K 39/ 39( . ) (86) International application number: PCT/EP1994/000448 (87) International publication number: WO 1994/019013 (01.09.1994 Gazette 1994/20)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.02.1993 US 19930021535 01.09.1993 US 19930115570 (71) Applicants: SMITHKLINE BEECHAM CORPORATION Philadelphia, PA 19102 (US) SMITHKLINE BEECHAM BIOLOGICALS s.a. B-1330 Rixensart (BE)

(72) Inventors: DILLON, Susan Chadds Ford, PA 19317 (US) NISHIKAWA, Hirotoshi Haverford, PA 19041 (US) MONTE, Paul, Dal Exton, PA 19341 (US) GYURICK, Robert, J. Exeter, NH 03833 (US) GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude 89, rue de l'Institut, B-1330 Rixensart (BE) (74) Representative: Thompson, Clive Beresford, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)