(19)

(11)

EP 0 686 040 A1

(12)

(43) Date of publication: 13.12.1995 Bulletin 1995/50 (21) Application number: 94907292.0 (22) Date of filing: 25.01.1994

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61K 38/ 30( . ) A61P 43/ 00( . ) C07K 14/ 47( . ) A61K 38/ 27( . ) A61P 17/ 00( . ) C07K 1/ 113( . ) C07K 14/ 65( . ) (86) International application number: PCT/US1994/000799 (87) International publication number: WO 1994/016723 (04.08.1994 Gazette 1994/18)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.01.1993 US 19930011031 (71) Applicant: AMGEN BOULDER INC. Boulder, CO 80301-2546 (US)	(72) Inventors: COX, George N. Louisville, CO 80027 (US) MUSTOE, Thomas A. Northwestern Univ. Med. School Chicago, IL 60611-3042 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 D-80538 München D-80538 München (DE)