(19)

(11)

EP 0 686 200 A1

(12)

(43) Date of publication: 13.12.1995 Bulletin 1995/50 (21) Application number: 94907278.0 (22) Date of filing: 25.01.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12Q 1/ 68( . ) C07H 21/ 04( . ) (86) International application number: PCT/US1994/000748 (87) International publication number: WO 1994/017210 (04.08.1994 Gazette 1994/18)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.01.1993 US 19930010433 16.12.1993 US 19930168621 (71) Applicant: ONCOR, INC. Gaithersburg Maryland 20877 (US)	(72) Inventors: BHATNAGAR, Satish K. Gaithersburg, MD 20878 (US) GEORGE, Albert L., Jr. Gaithersburg, MD 20878 (US) (74) Representative: Browne, Robin Forsythe, Dr.  Urquhart-Dykes & Lord Tower House Merrion Way Leeds LS2 8PA West Yorkshire Leeds LS2 8PA West Yorkshire (GB)