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(11)

EP 0 688 218 A1

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(43) Date of publication: 27.12.1995 Bulletin 1995/52 (21) Application number: 94907087.0 (22) Date of filing: 22.02.1994

(51) International Patent Classification (IPC):  A61K 31/ 47( . ) (86) International application number: PCT/JP1994/000266 (87) International publication number: WO 1994/020105 (15.09.1994 Gazette 1994/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL PT SE (30) Priority: 10.03.1993 JP 19930048501 (71) Applicant: OTSUKA PHARMACEUTICAL CO., LTD. Chiyoda-ku Tokyo 101 (JP)	(72) Inventors: ADACHI, Masakazu Takasaki-shi, Gunma 370 (JP) TAMAOKA, Hisashi Itano-gun, Tokushima 771-02 (JP) ONO, Yukihisa Itano-gun Tokushima 771-02 (JP) (74) Representative: von Kreisler, Alek, Dipl.-Chem., et al  Patentanwälte, von Kreisler-Selting-Werner, Bahnhofsvorplatz 1 (Deichmannhaus) D-50667 Köln D-50667 Köln (DE)