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(11)

EP 0 689 602 A1

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(43) Date of publication: 03.01.1996 Bulletin 1996/01 (21) Application number: 94909987.0 (22) Date of filing: 21.03.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 31/ 70( . ) A61K 48/ 00( . ) C07K 14/ 16( . ) C07K 14/ 705( . ) C12N 5/ 10( . ) C12N 15/ 867( . ) A01K 67/ 027( . ) A61K 38/ 45( . ) A61P 31/ 12( . ) C07K 14/ 61( . ) C07K 14/ 805( . ) C12N 15/ 85( . ) A61K 38/ 00( . ) (86) International application number: PCT/GB1994/000568 (87) International publication number: WO 1994/021806 (29.09.1994 Gazette 1994/22)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 19.03.1993 GB 19930005759 (71) Applicants: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB) Therexsys Limited Keele, Staffordshire ST5 5SP (GB)

(72) Inventors: DZIERZAK, Elaine, Anne 40 Patshall Road London NW5 2JY (GB) BRADY, Hugh, Joseph, Martin 6 Coolhurst Road London N8 8EL (GB) MILES, Colin, Graham Gloucester GL2 0QS (GB) PENNINGTON, Daniel, John 5 Merefield Chorley Lancashire PR7 1VP (GB) ABRAHAM, David, John 12 Cedar Close Kent ME20 6EN (GB) CRAIG, Roger, Kingdon Jubilee House Farm Sandbach Cheshire CW11 0XA (GB) (74) Representative: Hallybone, Huw George  CARPMAELS AND RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)